VUOS multi-purpose pilot plant is well-equipped with a range of glass-lined, stainless steel and rubber-lined reactors for flexible batch-wise production. They are grouped into production trains for a wide range of chemical and physical processes. Sufficient support by rectification units and auxiliary operations (e.g. for isolation of products) makes VÚOS a good partner for you.
We are able to develop processes based on our own know-how, or to scale-up and/or optimise existing processes for full commercial production. We co-operate with interesting outsourcing partners on new important pharma-projects.
Pilot plant production is mostly orientated towards VUOS custom syntheses activities [usually under secrecy agreement] ranging in volume from ten kilos to ten tons.
Production is mainly directed into the field of pharmaceutical intermediates ["starting materials"].
The manufacturing service is supported by a highly experienced team of chemists and chemical engineers, with a special expertise in adapting processes and plant layout to manufacture a wide range of speciality/fine chemicals (see our Product List).
We are able to handle some obnoxious/hazardous chemicals, e.g.
|
Material |
Total volume [l] |
Size |
Number |
|
|---|---|---|---|---|
|
From [l] |
To [l] |
|||
|
Glass Lined |
65 600 |
125 |
4 000 |
51 |
|
Stainless Steel |
14 000 |
50 |
3 000 |
13 |
|
Steel(CS) |
4 900 |
700 |
2 000 |
4 |
|
Rubber-lined |
37 700 |
1 000 |
5 000 |
12 |
|
Ceramic-lined |
12 000 |
4 000 |
4 000 |
3 |
|
Unit |
Material |
Boiler [l] |
Theoretical Plates |
Pressure |
Temperature [oC] |
Using |
|---|---|---|---|---|---|---|
|
1 |
SS |
500 |
20 |
4 mbar vacuum |
220 |
for material with melting point up to 110°C |
|
2 |
SS |
2000 |
80 |
100 mbar vacuum |
150 |
|
|
3 |
SS |
1000 |
20 |
100 mbar vacuum |
150 |
|
|
4 |
glass lined/glass |
400 |
20 (Mellacarbon) |
15 mbar vacuum |
150 |
(for azeotropic rectification) |
|
5 |
glass lined/glass |
2500 |
35 (Mellacarbon) |
15 mbar vacuum |
200 |
|
|
6 |
glass lined/glass |
1600 |
7 (ceramic pack.) |
100 mbar vacuum |
150 |
(for azeotropic rectification) |
|
7 |
glass lined/glass |
1600 |
7 (ceramic pack.) |
100 mbar vacuum |
150 |
|
|
8 |
glass lined/glass |
1200 |
25 (Kerapac) |
15 mbar vakuum |
150 |
(for azeotropic rectification) |
|
Volume |
Material of construction |
Max. operating pressure [MPa] |
Max. operating temperature [°C] |
|---|---|---|---|
|
300 |
CS, Hastelloy C4 |
12 |
140 |
|
100 |
SS |
13 |
200 |
|
100 |
CS, Hastelloy C4 |
6 |
140 |
|
10 |
SS |
10 |
250 |
|
1 |
SS |
30 |
350 |
|
0.25 - 3 |
glass |
1.2 |
200 |
|
0.5 - 1 |
SS |
6 |
250 |
|
5 |
SS |
4 |
250 |
|
1000 |
SS |
1 |
140 |
Rectification Distillation
Rectification stills equipped with high performance packing (SS, Sulzer type), ranging in performance up to 60 theoretical plates.
Rectification still with conventional packing, separation performance 100 theoretical plates. Atmospheric / vacuum operation, fully automatic control system.
Distillation
Wiped-film rotary evaporator (glass, 0.1 m 2 evaporation surface, operating vacuum down to 0.8 torr). Optionally can be built in a rectification unit (ca 20 theoretic plates) as a film boiler.
Short-path evaporator - glass, operating temperature up to 250 deg C, vacuum down to 0.2 torr.
Hydrogenation
Experience collected mainly in areas of catalytic hydrogenation of nitro-groups (to resp. amines), carbonyl-groups (to alcohols), oximes (to amino-groups) and reductive cyclisation.
Operating conditions: pressure up to 20 bar, batch volume up to 8 l, temperature up to 150 deg C. Automatic control & monitoring, possibility to be run in a semi-continuous regime (reactants feeding during reaction by metering pumps).
Pressure operation
Typical operations include alkylations, aminations, oxidations, pressure re-crystallisation.
Operating conditions: pressure up to 50 bar, heating up to 250°C (automatical control), possibility to be run in a semi-continuous way (see above).
Lower-temperature syntheses
Used mainly for special chlorinations (using PCl5) and nitrations in jacketed glass equipment. Operating conditions: temperature typically at - 25°C, batch volume up to 20 l, semi-continuous regime possible, inert gas blanketing as a standard.
Under construction
wiped film rotary evaporator, stainless steel, 0.3 m 2, 200°C, 1 mbar vacuum
wiped film rotary evaporator, stainless steel, 0.7 m 2, 200°C, 1 mbar vacuum
Auxiliary equipment
In addition, the reactors are equipped with various accessories for distilling, azeotropic distillation, reflux, and computer control system of operating conditions. The apparatuses are connected with absorption and adsorption units. Numerous tanks, pumps, piping [stainless, glass, plastic] and hose connection sections [PTFE], mixers, dryers and heat transfer systems [steam, brine and hot oil] are available.